CAMK2A/CAMK2D

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Postsynaptic lipid rafts.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.,

G1/S transition of mitotic cell cycle, mitotic cell cycle, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, ion transport, cation transport, calcium ion transport, cell cycle, di-, tri-valent inorganic cation transport, phosphorylation, cell cycle process, cell cycle phase, metal ion transport, regulation of neurological system process, positive regulation of DNA binding, regulation of system process, positive regulation of molecular function, regulation of transcription, protein amino acid autophosphorylation, regulation of neurotransmitter secretion, regulation of synaptic plasticity, regulation of neuronal synaptic plasticity, regulation of synaptic transmission, regulation of secretion, regulation of transcription factor activity, positive regulation of transcription factor activity, positive regulation of NF-kappaB transcription factor activity, regulation of binding, positive regulation of binding, regulation of DNA binding, interphase, interphase of mitotic cell cycle, regulation of neurotransmitter transport, regulation of transmission of nerve impulse, regulation of cellular localization,

Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, dendrite . Postsynaptic lipid rafts. .