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C/EBP β (Phospho Thr235) Cell-Based Colorimetric ELISA Kit

-KA1043C

Catalog: KA1043C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CEBPB
show all
Other Name:
CCAAT/enhancer-binding protein beta ;
C/EBP beta ;
Liver activator protein ;
Nuclear factor NF-IL6 ;
Transcription factor 5 ;
TCF-5 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 1051; P17676;
Mouse P28033;
Rat P21272;
Background:
function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'.,PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2.,tissue specificity:Expressed at low levels in the lung, kidney and spleen.,
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Function:
in utero embryonic development, regulation of cytokine production, placenta development, embryonic placenta development, acute inflammatory response, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, anti-apoptosis, induction of apoptosis, defense response, acute-phase response, inflammatory response,immune response, response to wounding, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, positive regulation of cell death, induction of programmed cell death, neuron differentiation, positive regulation of cellular biosynthetic process, regulation of interleukin-6 production, RNA biosynthetic process, regulation of cytokine biosynthetic process,regulation of apoptosis, chordate embryonic development, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, regulation of interleukin-6 biosynthetic process, fat cell differentiation, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, embryonic organ development, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, negative regulation of cell death,
show all
Cellular Localization:
Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). .
show all
Tissue Expression:
Expressed at low levels in the lung, kidney and spleen.
show all
Catalog: KA1043C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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