ATP1A1

Sodium/potassium-transporting ATPase subunit alpha-1 ;
Na ;
+ ;
/K ;
+ ;
ATPase alpha-1 subunit ;
Sodium pump subunit alpha-1 ;

catalytic activity:ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).,function:This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.,PTM:Phosphorylation on Tyr-10 modulates pumping activity.,similarity:Belongs to the cation transport ATPase (P-type) family.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1.,

regulation of the force of heart contraction, circulatory system process, purine nucleotide metabolic process, purine nucleotide biosynthetic process, ATP biosynthetic process, ion transport, cation transport, potassium ion transport,sodium ion transport, regulation of muscle contraction, regulation of striated muscle contraction, blood circulation,regulation of heart contraction, regulation of blood pressure, nucleoside triphosphate metabolic process, nucleoside triphosphate biosynthetic process, purine nucleoside triphosphate metabolic process, purine nucleoside triphosphate biosynthetic process, purine ribonucleotide metabolic process, purine ribonucleotide biosynthetic process, nucleotide biosynthetic process, ribonucleoside triphosphate metabolic process, ribonucleoside triphosphate biosynthetic process, purine ribonucleoside triphosphate metabolic process, purine ribonucleoside triphosphate biosynthetic process, ribonucleotide metabolic process, ribonucleotide biosynthetic process, negative regulation of biosynthetic process, negative regulation of steroid biosynthetic process, monovalent inorganic cation transport, regulation of lipid metabolic process, regulation of steroid metabolic process, metal ion transport, negative regulation of cellular biosynthetic process, regulation of glucocorticoid metabolic process, negative regulation of glucocorticoid metabolic process, regulation of glucocorticoid biosynthetic process, negative regulation of glucocorticoid biosynthetic process,regulation of hormone metabolic process, negative regulation of hormone metabolic process, negative regulation of hormone biosynthetic process, nucleobase, nucleoside and nucleotide biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process, response to drug, regulation of system process, nitrogen compound biosynthetic process, negative regulation of heart contraction, positive regulation of heart contraction, negative regulation of lipid metabolic process, positive regulation of muscle contraction, negative regulation of steroid metabolic process, positive regulation of striated muscle contraction, ATP metabolic process, regulation of hormone biosynthetic process, regulation of lipid biosynthetic process, regulation of steroid biosynthetic process, negative regulation of lipid biosynthetic process, positive regulation of multicellular organismal process, negative regulation of multicellular organismal process,

Basolateral cell membrane ; Multi-pass membrane protein . Cell membrane, sarcolemma ; Multi-pass membrane protein . Cell projection, axon . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .