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4E-BP1 (Phospho Thr69) Cell-Based Colorimetric ELISA Kit

-KA1005C

Catalog: KA1005C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Target

4E-BP1

Reactivity

Human, Mouse, Rat, Chicken(testedbyourcustomer), Monkey

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
EIF4EBP1
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Protein Name:
Eukaryotic translation initiation factor 4E-binding protein 1
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Other Name:
EIF4EBP1 ;
Eukaryotic translation initiation factor 4E-binding protein 1 ;
4E-BP1 ;
eIF4E-binding protein 1 ;
Phosphorylated heat- and acid-stable protein regulated by insulin 1 ;
PHAS-I
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Database Link:
Organism Gene ID SwissProt
Human 1978; Q13541;
Mouse 13685; Q60876;
Rat 116636; Q62622;
Background:
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],
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Function:
Function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.,PTM:Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the eIF4E-binding protein family.,subunit:Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.,
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Cellular Localization:
Nucleus
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Tissue Expression:
Colon,Epithelium,Lung,Placenta,Platelet,
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Research Areas:
>>EGFR tyrosine kinase inhibitor resistance ;
>>ErbB signaling pathway ;
>>HIF-1 signaling pathway ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Cellular senescence ;
>>Insulin signaling pathway ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Herpes simplex virus 1 infection ;
>>Chemical carcinogenesis - receptor activation ;
>>Acute myeloid leukemia ;
>>Choline metabolism in cancer
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Catalog: KA1005C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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