Catalog: YP1841
Size
Price
Status
Qty.
200μL
$936.00
3 weeks
0
100μL
$560.00
3 weeks
0
50μL
$300.00
3 weeks
0
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Collected
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Main Information
Target
B-Myb Phospho Thr494
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC
MW
80kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
This antibody detects endogenous B-Myb when phosphorylated at thr494(human),thr497(mosue)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
80kD
Modification
phosphate
Clonality
Polyclonal
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human B-Myb (Phospho Thr494/497)
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Specificity:
This antibody detects endogenous B-Myb when phosphorylated at thr494(human),thr497(mosue)
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Gene Name:
MYBL2 BMYB
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Protein Name:
Myb-related protein B (B-Myb) (Myb-like protein 2)
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Other Name:
Myb-related protein B ;
B-Myb ;
Myb-like protein 2 ;
B-Myb ;
Myb-like protein 2 ;
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Background:
MYB proto-oncogene like 2 (MYBL2) Homo sapiens The protein encoded by this gene , a member of the MYB family of transcription factor genes , is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2 , cyclin D1 , and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2013] ,
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Function:
Function:Transcription factor involved in the regulation of cell survival , proliferation , and differentiation. Transactivates the expression of the CLU gene. ,PTM:Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity. ,similarity:Contains 3 HTH myb-type DNA-binding domains. ,subunit:Component of the DREAM complex (also named LINC complex) at least composed of E2F4 , E2F5 , LIN9 , LIN37 , LIN52 , LIN54 , MYBL1 , MYBL2 , RBL1 , RBL2 , RBBP4 , TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9 , LIN37 , LIN52 and LIN54 form a subcomplex that binds to MYBL22. ,
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Cellular Localization:
Nucleus.
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Research Areas:
>>Cellular senescence
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1841
Size
Price
Status
Qty.
200μL
$936.00
3 weeks
0
100μL
$560.00
3 weeks
0
50μL
$300.00
3 weeks
0
Add to cart
Collected
Collect
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