Synthesized peptide derived from human Estrogen Receptor-α (Phospho Thr311)

This antibody detects endogenous levels of Estrogen Receptor-α (Phospho Thr311) Rabbit pAb at Human, Mouse,Rat

ESR1 ESR NR3A1

Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)

Estrogen receptor ;
ER ;
ER-alpha ;
Estradiol receptor ;
Nuclear receptor subfamily 3 group A member 1 ;

estrogen receptor 1 (ESR1) Homo sapiens This gene encodes an estrogen receptor , a ligand-activated transcription factor composed of several domains important for hormone binding , DNA binding , and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function , but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer , endometrial cancer , and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants , but the full-length nature of many of these variants has not been determined. [provided by RefSeq , Mar 2014] ,

Domain:Composed of three domains: a modulating N-terminal domain , a DNA-binding domain and a C-terminal steroid-binding domain. ,Function:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. ,online information:Estrogen receptor entry ,polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD) . Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density , disrutption of bone microarchitecture , and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture. ,PTM:Glycosylated; contains N-acetylglucosamine , probably O-linked. ,PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity. ,similarity:Belongs to the nuclear hormone receptor family. ,similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily. ,similarity:Contains 1 nuclear receptor DNA-binding domain. ,subunit:Interacts with SLC30A9 (By similarity) . Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3 , NCOA5 and NCOA6 coactivators , leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2 , PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2 , FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. ,

[Isoform 1]: Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . A minor fraction is associated with the inner membrane.; [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Associated with the inner membrane via palmitoylation (Probable) . At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. .; Nucleus. Golgi apparatus. Cell membrane. Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.

>>Endocrine resistance ;
>>Estrogen signaling pathway ;
>>Prolactin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Breast cancer