Catalog: YP1552
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
WIPI2 Phospho Ser413
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
49kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat WIPI2 (phospho-Ser413)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
49kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human WIPI2 (Ser413)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat WIPI2 (phospho-Ser413)
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Gene Name:
WIPI2 CGI-50
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Protein Name:
WD repeat domain phosphoinositide-interacting protein 2
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Other Name:
WD repeat domain phosphoinositide-interacting protein 2 ;
WIPI-2 ;
WIPI49-like protein 2 ;
WIPI-2 ;
WIPI49-like protein 2 ;
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Database Link:
Background:
WD repeat domain , phosphoinositide interacting 2 (WIPI2) Homo sapiens WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins , such as WIPI2 , have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al. , 2004 [PubMed 15602573]) .[supplied by OMIM , Mar 2008] ,
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Function:
similarity:Contains 3 WD repeats. ,tissue specificity:Ubiquitously expressed. Highly expressed in heart , skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. ,
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Cellular Localization:
Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .
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Tissue Expression:
Research Areas:
>>Autophagy - other ;
>>Autophagy - animal ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis
>>Autophagy - animal ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Huntington disease
Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
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Catalog: YP1552
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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