Catalog: YP1535
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
TPOR Phospho Tyr626
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
69,40kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human TPOR (phospho-Tyr626)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
69,40kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human TPOR (Tyr626)
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Specificity:
This antibody detects endogenous levels of Human TPOR (phospho-Tyr626)
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Gene Name:
MPL TPOR
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Protein Name:
Thrombopoietin receptor (Tyr626)
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Other Name:
MPL ;
TPOR ;
Thrombopoietin receptor ;
TPO-R ;
Myeloproliferative leukemia protein ;
Proto-oncogene c-Mpl ;
CD110
TPOR ;
Thrombopoietin receptor ;
TPO-R ;
Myeloproliferative leukemia protein ;
Proto-oncogene c-Mpl ;
CD110
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Background:
In 1990 an oncogene , v-mpl , was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue , named , c-mpl , was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl , thrombopoietin , was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene , CD110 , is a 635 amino acid transmembrane domain , with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic , emphasizing the important
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Function:
Caution:It is uncertain whether Met-1 or Met-8 is the initiator. ,Disease:Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. ,Domain:The box 1 motif is required for JAK interaction and/or activation. ,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. ,Function:Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. ,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily. ,similarity:Contains 2 fibronectin type-III domains. ,subunit:Interacts with ATXN2L. ,tissue specificity:Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. ,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein. Golgi apparatus . Cell surface .
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Tissue Expression:
Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>JAK-STAT signaling pathway
>>JAK-STAT signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1535
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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