Catalog: YP1526
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
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Collected
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Main Information
Target
TAZ Phospho Ser89
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
44kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat TAZ (phospho-Ser89)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
44kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human TAZ (Ser89)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat TAZ (phospho-Ser89)
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Gene Name:
WWTR1 TAZ
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Protein Name:
WW domain-containing transcription regulator protein 1
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Other Name:
WW domain-containing transcription regulator protein 1 ;
Transcriptional coactivator with PDZ-binding motif ;
Transcriptional coactivator with PDZ-binding motif ;
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Function:
Domain:Binds to transcription factors via its WW domain. ,Domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes. ,Function:Functions as a transcriptional coactivator. ,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export. ,similarity:Contains 1 WW domain. ,subcellular location:Concentrates along specific portions of the plasma membrane , and accumulates in punctate nuclear bodies. When phosphorylated , is retained in cytoplasm by YWHAZ. ,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. ,tissue specificity:Highly expressed in kidney , heart , placenta and lung. ,
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Cellular Localization:
Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane , and accumulates in punctate nuclear bodies (By similarity) . When phosphorylated , is retained in the cytoplasm by YWHAZ (By similarity) . Can be retained in the nucleus by MED15 (PubMed:18568018) . Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499) . At blastocyst stage expressed in the nucleus in trophectodermal cells , however expressed in the cytoplasm in the inner cell mass (By similarity) . .
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Tissue Expression:
Research Areas:
>>Hippo signaling pathway ;
>>Hippo signaling pathway - multiple species
>>Hippo signaling pathway - multiple species
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1526
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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