Synthesized phosho peptide around human Syk (Ser297)

This antibody detects endogenous levels of Human Syk (phospho-Ser297)

SYK

Syk (Ser297)

SYK ;
Tyrosine-protein kinase SYK ;
Spleen tyrosine kinase ;
p72-Syk

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses , including proliferation , differentiation , and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Mar 2010] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway , when not phosphorylated on tyrosines of the linker region , or through a phospholipase C-gamma-dependent pathway , when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. ,PTM:Autophosphorylated. ,PTM:Phosphorylation on Tyr-323 creates a binding site for c-Cbl , an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. ,PTM:Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway. ,PTM:Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 SH2 domains. ,subunit:Interacts with CBL and SLA when it is phosphorylated. The interaction with SLA may link it to CBL , leading to its destruction. Interacts with phosphorylated NFAM1 (By similarity) . Interacts with Epstein-Barr virus LMP2A. Interacts through its SH2 domains with the phosphorylated ITAM domain of CD79A which stimulates SYK autophosphorylation and activation. Interacts with FCRL3. ,

Cell membrane . Cytoplasm , cytosol .

>>NF-kappa B signaling pathway ;
>>Phospholipase D signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Osteoclast differentiation ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>C-type lectin receptor signaling pathway ;
>>Natural killer cell mediated cytotoxicity ;
>>B cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>Fc gamma R-mediated phagocytosis ;
>>Tuberculosis ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Coronavirus disease - COVID-19 ;
>>Viral carcinogenesis