Synthesized phosho peptide around human Src (Ser17)

This antibody detects endogenous levels of Human Mouse Rat Src (phospho-Ser17)

SRC SRC1

Src (Ser17)

SRC ;
SRC1 ;
Proto-oncogene tyrosine-protein kinase Src ;
Proto-oncogene c-Src ;
pp60c-src ;
p60-Src

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,PTM:Phosphorylated on Tyr-530 by c-Src kinase (CSK) . The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 1 SH3 domain. ,subunit:Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1 (By similarity) . Interacts with CDCP1 , PELP1 , TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of MUC1 , phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the SH3 domain. Interacts with HEV ORF3 protein; via the SH3 domain. ,

Cell membrane ; Lipid-anchor . Mitochondrion inner membrane . Nucleus . Cytoplasm , cytoskeleton . Cytoplasm , perinuclear region . Cell junction , focal adhesion . Localizes to focal adhesion sites following integrin engagement (PubMed:22801373) . Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268) . Colocalizes with PDLIM4 at the perinuclear region , but not at focal adhesions (PubMed:19307596) . .

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>ErbB signaling pathway ;
>>Rap1 signaling pathway ;
>>Chemokine signaling pathway ;
>>Mitophagy - animal ;
>>Endocytosis ;
>>Axon guidance ;
>>VEGF signaling pathway ;
>>Focal adhesion ;
>>Adherens junction ;
>>Tight junction ;
>>Gap junction ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>C-type lectin receptor signaling pathway ;
>>GABAergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>Regulation of actin cytoskeleton ;
>>GnRH signaling pathway ;
>>Estrogen signaling pathway ;
>>Prolactin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Oxytocin signaling pathway ;
>>Relaxin signaling pathway ;
>>Bacterial invasion of epithelial cells ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Yersinia infection ;
>>Tuberculosis ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Bladder cancer ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis