Synthesized phosho peptide around human Shc (Tyr317)

This antibody detects endogenous levels of Human Mouse Shc (phospho-Tyr317)

SHC1 SHC SHCA

Shc (Tyr317)

SHC-transforming protein 1 ;
SHC-transforming protein 3 ;
SHC-transforming protein A ;
Src homology 2 domain-containing-transforming protein C1 ;
SH2 domain protein C1 ;

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways , the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms , p52Shc and p46Shc , link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms , p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Feb 2011] ,

Domain:In response to a variety of growth factors , isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr (P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation. ,Function:Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc , once phosphorylated , couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation , but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants , cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. ,PTM:Phosphorylated by activated epidermal growth factor receptor. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 upon treatment with insulin , hydrogen peroxide or irradiation with ultraviolet light. ,similarity:Contains 1 PID domain. ,similarity:Contains 1 SH2 domain. ,subcellular location:Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids , which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc , that contain the same sequence but more internally located , display a different subcellular localization. ,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated , binds to GRB2. Interacts with tyrosine-phosphorylated CD3T. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. ,tissue specificity:Widely expressed. Expressed in neural stem cells but absent in mature neurons. ,

Cytoplasm.; [Isoform p46Shc]: Mitochondrion matrix . Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids , which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc , that contain the same sequence but more internally located , display a different subcellular localization.; [Isoform p66Shc]: Mitochondrion . In case of oxidative conditions , phosphorylation at 'Ser-36' of isoform p66Shc , leads to mitochondrial accumulation. .

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Focal adhesion ;
>>Natural killer cell mediated cytotoxicity ;
>>Neurotrophin signaling pathway ;
>>Insulin signaling pathway ;
>>Estrogen signaling pathway ;
>>Prolactin signaling pathway ;
>>Relaxin signaling pathway ;
>>Growth hormone synthesis , secretion and action ;
>>Alcoholism ;
>>Bacterial invasion of epithelial cells ;
>>MicroRNAs in cancer ;
>>Glioma ;
>>Chronic myeloid leukemia ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer