Catalog: YP1465
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
NR1D1 Phospho Ser55/59
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
67kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Rev-erbα only when phosphorylated at Ser55 or 59,and dually phosphorylated at two sites.
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
67kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human Rev-erbα (Ser55 and 59)
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Specificity:
This antibody detects endogenous levels of Rev-erbα only when phosphorylated at Ser55 or 59,and dually phosphorylated at two sites.
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Gene Name:
NR1D1 EAR1 HREV THRAL
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Protein Name:
Rev-erbα (Ser55/59)
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Other Name:
NR1D1 ;
EAR1 ;
HREV ;
THRAL ;
Nuclear receptor subfamily 1 group D member 1 ;
Rev-erbA-alpha ;
V-erbA-related protein 1 ;
EAR-1
EAR1 ;
HREV ;
THRAL ;
Nuclear receptor subfamily 1 group D member 1 ;
Rev-erbA-alpha ;
V-erbA-related protein 1 ;
EAR-1
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Database Link:
Background:
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) . This protein may also be involved in regulating genes that function in metabolic , inflammatory and cardiovascular processes. [provided by RefSeq , Jan 2013] ,
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Function:
Domain:Composed of three domains: a modulating N-terminal domain , a DNA-binding domain and a C-terminal steroid-binding domain. ,Function:Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine. ,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily. ,similarity:Contains 1 nuclear receptor DNA-binding domain. ,subunit:Interacts with C1D. ,tissue specificity:Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines. ,
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Cellular Localization:
Nucleus . Cytoplasm . Cell projection , dendrite . Cell projection , dendritic spine . Localizes to the cytoplasm , dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization. .
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Research Areas:
>>Circadian rhythm
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1465
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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