Catalog: YP1449
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
PRAS40 Phospho Ser183
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, ELISA
MW
40kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse PRAS40 (phospho-Ser183)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
40kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
Related Products
Primary Antibodies
PRAS40 Rabbit pAb
YT3850
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Primary Antibodies
PRAS40 (Phospho Thr246) Rabbit pAb
YP0302
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ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
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ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
KA1267C
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human PRAS40 (Ser183)
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Specificity:
This antibody detects endogenous levels of Human Mouse PRAS40 (phospho-Ser183)
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Gene Name:
AKT1S1 PRAS40
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Protein Name:
PRAS40 (Ser183)
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Other Name:
AKT1S1 ;
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
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Background:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH , MIM 113508) when phosphorylated (Kovacina et al. , 2003 [PubMed 12524439]) .[supplied by OMIM , Mar 2008] ,
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Function:
Function:May play an important role in phosphatidylinositol 3-kinase (PI3K) -AKT1 survival signaling. Substrate for AKT1 phosphorylation , but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection. ,subcellular location:Found in the cytosolic fraction of the brain. ,subunit:The phosphorylated form interacts with 14-3-3. ,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293) . ,
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Cellular Localization:
Cytoplasm , cytosol . Found in the cytosolic fraction of the brain. .
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Tissue Expression:
Research Areas:
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Thermogenesis ;
>>Shigellosis
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Thermogenesis ;
>>Shigellosis
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Reference Citation({{totalcount}})
Catalog: YP1449
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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