Catalog: YP1392
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
MARCKS Phospho Ser159/163
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
32kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser159 or Ser163,and dually phosphorylated at two sites.
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
32kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human MARCKS (Ser159 and 163)
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Specificity:
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser159 or Ser163,and dually phosphorylated at two sites.
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Gene Name:
MARCKS MACS PRKCSL
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Protein Name:
MARCKS (Ser159/163)
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Other Name:
Myristoylated alanine-rich C-kinase substrate ;
MARCKS ;
Protein kinase C substrate,80 kDa protein,light chain ;
80K-L protein ;
PKCSL ;
MARCKS ;
Protein kinase C substrate,80 kDa protein,light chain ;
80K-L protein ;
PKCSL ;
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Background:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane , leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility , phagocytosis , membrane trafficking and mitogenesis. [provided by RefSeq , Jul 2008] ,
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Function:
Function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin , actin , and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. ,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. ,similarity:Belongs to the MARCKS family. ,
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Cellular Localization:
Cytoplasm , cytoskeleton . Membrane ; Lipid-anchor .
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Tissue Expression:
Research Areas:
>>Fc gamma R-mediated phagocytosis ;
>>MicroRNAs in cancer
>>MicroRNAs in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1392
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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