Catalog: YK0160
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
MyoD1 Acetyl Lys99/102
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
69kD (Observed)
Conjugate/Modification
Acetyl
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of MyoD only when acetylated at Ser99 or Lys102and dually acetylated at two sites..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):kACkR
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
69kD
Modification
Acetyl
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human MyoD (Acetyl Lys99/K102)
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Specificity:
This antibody detects endogenous levels of MyoD only when acetylated at Ser99 or Lys102and dually acetylated at two sites..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):kACkR
show all
Gene Name:
MYOD1 BHLHC1 MYF3 MYOD
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Protein Name:
MyoD (Acetyl Lys99/K102)
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Other Name:
MYOD1 ;
BHLHC1 ;
MYF3 ;
MYOD ;
Myoblast determination protein 1 ;
Class C basic helix-loop-helix protein 1 ;
bHLHc1 ;
Myogenic factor 3 ;
Myf-3
BHLHC1 ;
MYF3 ;
MYOD ;
Myoblast determination protein 1 ;
Class C basic helix-loop-helix protein 1 ;
bHLHc1 ;
Myogenic factor 3 ;
Myf-3
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Database Link:
Background:
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008],
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Function:
Function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.,online information:MyoD entry,PTM:Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.,PTM:Ubiquitinated on the N-terminus; which is required for proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.,
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Cellular Localization:
Nucleus.
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Research Areas:
>>Spinocerebellar ataxia
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Signaling Pathway
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Catalog: YK0160
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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