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Human TREM-1 ELISA Kit

-KE1259

Catalog: KE1259
Size
Price
Status
Qty.
5*96well
$1,850.00
3 weeks

0

2*96well
$740.00
3 weeks

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96well
$370.00
3 weeks

0

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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Specificity
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Storage
2-8°C/6 months
Modification
Unmodified
Sample Type
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Detection Method
Colorimetric
Sensitivity
94-6000 pg/mL
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Antigen&Target Information
Specificity:
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
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Gene Name:
TREM1
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Protein Name:
Triggering receptor expressed on myeloid cells 1
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Other Name:
TREM1 ;
Triggering receptor expressed on myeloid cells 1 ;
TREM-1 ;
Triggering receptor expressed on monocytes 1 ;
CD antigen CD354
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Database Link:
Organism Gene ID SwissProt
Human 54210; Q9NP99;
Mouse Q9JKE2;
Background:
function:Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.,induction:Up-regulated by bacteria, fungi and lipopolysaccharides (LPS).,PTM:Glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with TYROBP/DAP12.,tissue specificity:Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.,
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Function:
immune response, humoral immune response, intracellular signaling cascade,
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Cellular Localization:
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Recruited to lipid rafts when activated. .; [Isoform 2]: Secreted .
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Tissue Expression:
Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells (PubMed:10799849). Expression is associated with a mature stage of myeloid development (PubMed:11922939). Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.
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Catalog: KE1259
Size
Price
Status
Qty.
5*96well
$1,850.00
3 weeks

0

2*96well
$740.00
3 weeks

0

96well
$370.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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