Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

THBS1

Thrombospondin-1

THBS1 ;
TSP ;
TSP1 ;
Thrombospondin-1

function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 TSP type-1 domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homotrimer; disulfide-linked.,

MAPKKK cascade, activation of MAPK activity, angiogenesis, blood vessel development, response to hypoxia,regulation of cytokine production, negative regulation of cytokine production, positive regulation of cytokine production, regulation of endothelial cell proliferation, negative regulation of endothelial cell proliferation, vasculature development, regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, sprouting angiogenesis,chronic inflammatory response, regulation of antigen processing and presentation, negative regulation of antigen processing and presentation, regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, regulation of dendritic cell antigen processing and presentation, negative regulation of dendritic cell antigen processing and presentation, negative regulation of immune system process, positive regulation of immune system process, regulation of leukocyte migration, positive regulation of leukocyte migration, regulation of leukocyte chemotaxis, positive regulation of leukocyte chemotaxis, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of translation, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, endocytosis, phagocytosis, phagocytosis, engulfment, apoptosis, anti-apoptosis, cell motion, defense response, inflammatory response, immune response, cell cycle, cell cycle arrest, cell adhesion,negative regulation of cell adhesion, intracellular signaling cascade, protein kinase cascade, cell death, negative regulation of cell proliferation, response to temperature stimulus, response to heat, response to wounding, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, positive regulation of biosynthetic process,positive regulation of signal transduction, negative regulation of signal transduction, response to organic substance,response to inorganic substance, response to metal ion, membrane invagination, positive regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, regulation of endothelial cell migration,positive regulation of endothelial cell migration, negative regulation of endothelial cell migration, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, positive regulation of cell communication, negative regulation of cell communication,positive regulation of oxygen and reactive oxygen species metabolic process, regulation of plasma membrane long-chain fatty acid transport, negative regulation of plasma membrane long-chain fatty acid transport, regulation of nitric oxide mediated signal transduction, negative regulation of nitric oxide mediated signal transduction, regulation of cGMP-mediated signaling, negative regulation of cGMP-mediated signaling, regulation of plasminogen activation,negative regulation of plasminogen activation, regulation of macrophage chemotaxis, positive regulation of macrophage chemotaxis, regulation of fibroblast migration, positive regulation of fibroblast migration, regulation of cell-substrate adhesion, positive regulation of cell-substrate adhesion, negative regulation of cell-substrate adhesion,regulation of cell death, regulation of protein maturation by peptide bond cleavage, negative regulation of protein maturation by peptide bond cleavage, programmed cell death, membrane organization, vesicle-mediated transport,death, phosphorylation, cell migration, negative regulation of angiogenesis, regulation of transforming growth factor beta receptor signaling pathway, peptide cross-linking, regulation of phosphate metabolic process, cell cycle process,biological adhesion, regulation of cell adhesion, regulation of proteolysis, regulation of blood coagulation, positive regulation of blood coagulation, regulation of cell migration, positive regulation of cell migration, negative regulation of cell migration, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of cellular biosynthetic process, response to magnesium ion, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of lipid transport, negative regulation of lipid transport, response to progesterone stimulus, regulation of interleukin-12 production, negative regulation of interleukin-12 production, regulation of organic acid transport, negative regulation of organic acid transport, regulation of transforming growth factor-beta1 production, positive regulation of transforming growth factor-beta1 production, cellular response to stress, positive regulation of kinase activity,response to monosaccharide stimulus, cellular response to heat, regulation of locomotion, negative regulation of locomotion, positive regulation of locomotion, regulation of fibroblast growth factor receptor signaling pathway,negative regulation of fibroblast growth factor receptor signaling pathway, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, regulation of apoptosis, regulation of macrophage activation,positive regulation of macrophage activation, negative regulation of apoptosis, regulation of programmed cell death,negative regulation of programmed cell death, positive regulation of catalytic activity, apoptotic cell clearance,regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of blood vessel endothelial cell migration, positive regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell migration, regulation of kinase activity, engulfment of apoptotic cell, regulation of cellular component biogenesis,positive regulation of molecular function, positive regulation of translation, regulation of angiogenesis, positive regulation of angiogenesis, positive regulation of cell adhesion, regulation of protein kinase activity, positive regulation of protein kinase activity, negative regulation of proteolysis, positive regulation of phosphate metabolic process, blood vessel morphogenesis, positive regulation of behavior, response to steroid hormone stimulus, positive regulation of response to stimulus, cell motility, regulation of behavior, regulation of coagulation, positive regulation of coagulation, regulation of cell activation, positive regulation of cell activation, regulation of chemotaxis, positive regulation of chemotaxis, negative regulation of transport, positive regulation of developmental process, negative regulation of cellular component organization, regulation of phosphorus metabolic process, positive regulation of multicellular organismal process, negative regulation of multicellular organismal process, positive regulation of protein metabolic process, negative regulation of protein metabolic process, regulation of cell motion, negative regulation of cell motion, positive regulation of cell motion, regulation of transferase activity, positive regulation of transferase activity, response to calcium ion, localization of cell, regulation of focal adhesion formation, negative regulation of focal adhesion formation, regulation of fibrinolysis, negative regulation of fibrinolysis, negative regulation of cell death,response to oxygen levels, regulation of protein processing, regulation of oxygen and reactive oxygen species metabolic process,

Secreted . Cell surface . Secreted, extracellular space, extracellular matrix . Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). .