Catalog: KE1242
Size
Price
Status
Qty.
5*96well
$1,850.00
3 weeks
0
2*96well
$740.00
3 weeks
0
96well
$370.00
3 weeks
0
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Specificity
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Storage
2-8°C/6 months
Modification
Unmodified
Sample Type
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Detection Method
Colorimetric
Sensitivity
250-16000 pg/ml
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RS0002
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YM3028
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Antigen&Target Information
Specificity:
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
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Gene Name:
CTSB
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Protein Name:
Cathepsin B
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Other Name:
CTSB ;
CPSB ;
Cathepsin B ;
APP secretase ;
APPS ;
Cathepsin B1
CPSB ;
Cathepsin B ;
APP secretase ;
APPS ;
Cathepsin B1
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Background:
catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,
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Function:
proteolysis, response to wounding, regulation of cell death, regulation of apoptosis, regulation of programmed cell death,
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Cellular Localization:
Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
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Tissue Expression:
Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Lysosome
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Antigen processing and presentation
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Catalog: KE1242
Size
Price
Status
Qty.
5*96well
$1,850.00
3 weeks
0
2*96well
$740.00
3 weeks
0
96well
$370.00
3 weeks
0
Add to cart
Collected
Collect
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