Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

MPO

Myeloperoxidase

MPO ;
Myeloperoxidase ;
MPO

catalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO subfamily.,subunit:Tetramer of two light chains and two heavy chains.,

response to reactive oxygen species, oxygen and reactive oxygen species metabolic process, anti-apoptosis, defense response, response to oxidative stress, response to inorganic substance, regulation of cell death, cellular response to stress, macromolecular complex remodeling, protein-lipid complex remodeling, plasma lipoprotein particle remodeling,low-density lipoprotein particle remodeling, cellular response to oxidative stress, cellular response to reactive oxygen species, response to hydrogen peroxide, hydrogen peroxide metabolic process, hydrogen peroxide catabolic process,regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, macromolecular complex subunit organization, oxidation reduction, negative regulation of cell death, cellular response to hydrogen peroxide,

Lysosome.