Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TNFSF14

Tumor necrosis factor ligand superfamily member 14

TNFSF14 ;
HVEML ;
LIGHT ;
Tumor necrosis factor ligand superfamily member 14 ;
Herpes virus entry mediator ligand ;
HVEM-L ;
Herpesvirus entry mediator ligand ;
CD antigen CD258

function:Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.,induction:Up-regulated after T-cell activation.,PTM:N-glycosylated.,PTM:The soluble form of isoform 1 derives from the membrane form by proteolytic processing.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.,

cell activation, leukocyte homeostasis, lymphocyte homeostasis, positive regulation of immune system process,regulation of leukocyte activation, positive regulation of leukocyte activation, induction of apoptosis, immune response, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, cell proliferation, release of cytoplasmic sequestered NF-kappaB, regulation of cell death, positive regulation of cell death,induction of programmed cell death, lymphocyte costimulation, T cell costimulation, regulation of intracellular transport,positive regulation of intracellular transport, regulation of protein localization, mononuclear cell proliferation,regulation of intracellular protein transport, T cell proliferation, T cell activation, regulation of protein import into nucleus, positive regulation of protein import into nucleus, regulation of NF-kappaB import into nucleus, positive regulation of NF-kappaB import into nucleus, homeostatic process, regulation of apoptosis, regulation of transcription factor import into nucleus, positive regulation of transcription factor import into nucleus, T cell homeostasis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, leukocyte activation, lymphocyte activation, lymphocyte proliferation, regulation of nucleocytoplasmic transport, positive regulation of nucleocytoplasmic transport, homeostasis of number of cells, regulation of T cell activation, regulation of cell activation, positive regulation of cell activation, positive regulation of T cell activation, positive regulation of transport, positive regulation of protein transport, regulation of protein transport, regulation of lymphocyte activation,positive regulation of lymphocyte activation, regulation of cellular localization, regulation of establishment of protein localization, leukocyte proliferation,

[Tumor necrosis factor ligand superfamily member 14, membrane form]: Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted.; [Isoform 2]: Cytoplasm.

Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.