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Human IGFBP-3 ELISA Kit

-KE1230

Catalog: KE1230
Size
Price
Status
Qty.
5*96well
$1,850.00
3 weeks

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2*96well
$740.00
3 weeks

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96well
$370.00
3 weeks

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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Specificity
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Storage
2-8°C/6 months
Modification
Unmodified
Sample Type
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Detection Method
Colorimetric
Sensitivity
125-8000 pg/ml
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Antigen&Target Information
Specificity:
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
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Gene Name:
IGFBP3
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Protein Name:
Insulin-like growth factor-binding protein 3
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Other Name:
IGFBP3 ;
IBP3 ;
Insulin-like growth factor-binding protein 3 ;
IBP-3 ;
IGF-binding protein 3 ;
IGFBP-3
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Database Link:
Organism Gene ID SwissProt
Human 3486; P17936;
Mouse P47878;
Background:
developmental stage:IGFBP3 levels are higher during extrauterine life and peak during puberty.,domain:The thyroglobulin type-1 domain mediates interaction with HN.,function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.,induction:IGFBP3 levels increase in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, epidermal growth factor, and phorbol esters.,online information:The Singapore human mutation and polymorphism database,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.,tissue specificity:Expressed by most tissues.,
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Function:
skeletal system development, ossification, regulation of cell growth, osteoblast differentiation, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, negative regulation of cell proliferation, negative regulation of signal transduction, negative regulation of phosphorus metabolic process,negative regulation of macromolecule metabolic process, negative regulation of cell communication, regulation of cell death, positive regulation of cell death, regulation of smooth muscle cell migration, negative regulation of smooth muscle cell migration, regulation of striated muscle tissue development, phosphorylation, regulation of phosphate metabolic process, regulation of cell migration, negative regulation of cell migration, regulation of protein modification process, negative regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of growth, regulation of locomotion, negative regulation of locomotion, regulation of cell proliferation, regulation of phosphorylation, negative regulation of phosphorylation,regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of cell differentiation, regulation of myoblast differentiation, positive regulation of myoblast differentiation, negative regulation of phosphate metabolic process, regulation of muscle development, regulation of skeletal muscle tissue development, regulation of smooth muscle cell proliferation,negative regulation of smooth muscle cell proliferation, regulation of skeletal muscle fiber development, positive regulation of developmental process, regulation of muscle cell differentiation, positive regulation of muscle cell differentiation, regulation of striated muscle cell differentiation, regulation of phosphorus metabolic process, negative regulation of protein metabolic process, regulation of cell motion, negative regulation of cell motion, regulation of cell development, bone development,
show all
Cellular Localization:
Secreted .
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Tissue Expression:
Expressed by most tissues. Present in plasma.
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Catalog: KE1230
Size
Price
Status
Qty.
5*96well
$1,850.00
3 weeks

0

2*96well
$740.00
3 weeks

0

96well
$370.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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