Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CLU

Clusterin

CLU ;
APOJ ;
CLI ;
KUB1 ;
AAG4 ;
Clusterin ;
Aging-associated gene 4 protein ;
Apolipoprotein J ;
Apo-J ;
Complement cytolysis inhibitor ;
CLI ;
Complement-associated protein SP-40 ;
40 ;
Ku70-binding protein 1 ;
NA1/NA2 ;
Testosterone-repressed prostate m

function:Not yet clear. It is known to be expressed in a variety of tissues and it seems to be able to bind to cells, membranes and hydrophobic proteins. It has been associated with programmed cell death (apoptosis).,similarity:Belongs to the clusterin family.,subunit:Antiparallel disulfide-linked heterodimer. Interacts with APOA1, CLUAP1 AND PON1.,

cell morphogenesis, release of cytochrome c from mitochondria, adaptive immune response, immune effector process,activation of immune response, leukocyte mediated immunity, lymphocyte mediated immunity, humoral immune response mediated by circulating immunoglobulin, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, acute inflammatory response, activation of plasma proteins involved in acute inflammatory response, positive regulation of immune system process, proteolysis, lipid transport, apoptosis, anti-apoptosis, defense response, inflammatory response, immune response, complement activation, complement activation, classical pathway, humoral immune response, response to oxidative stress,mitochondrion organization, cell death, positive regulation of cell proliferation, apoptotic mitochondrial changes,response to wounding, lipid localization, regulation of cell death, programmed cell death, sterol transport,immunoglobulin mediated immune response, death, protein processing, B cell mediated immunity, cell projection organization, neuron differentiation, cholesterol transport, pancreas development, endocrine pancreas development,neuron projection development, negative regulation of protein complex assembly, regulation of protein oligomerization, negative regulation of protein oligomerization, regulation of protein homooligomerization, negative regulation of protein homooligomerization, cellular component morphogenesis, cell part morphogenesis, endocrine system development, regulation of cell proliferation, regulation of apoptosis, negative regulation of apoptosis,regulation of programmed cell death, negative regulation of programmed cell death, regulation of protein complex assembly, reverse cholesterol transport, regulation of cellular component biogenesis, innate immune response,positive regulation of cell differentiation, positive regulation of response to stimulus, neuron development, neuron projection morphogenesis, cell projection morphogenesis, positive regulation of immune response, positive regulation of developmental process, negative regulation of cellular component organization, protein maturation, protein maturation by peptide bond cleavage, negative regulation of cell death,

[Isoform 1]: Secreted . Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. .; [Isoform 4]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; [Isoform 6]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; Nucleus . Cytoplasm . Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cytosol . Microsome . Endoplasmic reticulum . Mitochondrion . Mitochondrion membrane . Cytoplasm, perinuclear region . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (PubMed:20068069). Detected at the mitochondrion membrane upon induction of apoptosis (PubMed:17689225). Under ER stress, a immaturely glycosylated pre-secreted form retrotranslocates from the endoplasmic reticulum (ER)-Golgi network to the cytoplasm to localize in the mitochondria through HSPA5 interaction (PubMed:22689054). ER stress reduces secretion (PubMed:22689054). Under the stress, minor amounts of non-secreted forms accumulate in cytoplasm (PubMed:24073260, PubMed:22689054, PubMed:17451556). Non-secreted forms emerge mainly from failed translocation, alternative splicing or non-canonical initiation start codon (PubMed:24073260, PubMed:12551933). .

Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.