Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CA9

Carbonic anhydrase 9

CA9 ;
G250 ;
MN ;
Carbonic anhydrase 9 ;
Carbonate dehydratase IX ;
Carbonic anhydrase IX ;
CA-IX ;
CAIX ;
Membrane antigen MN ;
P54/58N ;
Renal cell carcinoma-associated antigen G250 ;
RCC-associated antigen G250 ;
pMW1

catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,function:Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.,induction:By hypoxia.,PTM:Asn-346 bears high-mannose type glycan structures.,similarity:Belongs to the alpha-carbonic anhydrase family.,subcellular location:Found on the surface microvilli and in the nucleus, particularly in nucleolus.,subunit:Forms oligomers linked by disulfide bonds.,tissue specificity:Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.,

response to hypoxia, morphogenesis of an epithelium, one-carbon metabolic process, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to testosterone stimulus, response to drug, secretion, response to steroid hormone stimulus, tissue morphogenesis, epithelium development, response to oxygen levels,

Nucleus . Nucleus, nucleolus . Cell membrane ; Single-pass type I membrane protein . Cell projection, microvillus membrane ; Single-pass type I membrane protein . Found on the surface microvilli and in the nucleus, particularly in nucleolus.

Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.