Catalog: YP1317
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
DR6 Phospho Ser562
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
72kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat DR6 (phospho-Ser562)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
72kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human DR6 (Ser562)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat DR6 (phospho-Ser562)
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Gene Name:
TNFRSF21 DR6 UNQ437/PRO868
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Protein Name:
DR6 (Ser562)
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Other Name:
Tumor necrosis factor receptor superfamily member 21 ;
Death receptor 6 ;
CD antigen CD358 ;
Death receptor 6 ;
CD antigen CD358 ;
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Background:
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1) , and induces cell apoptosis. Through its death domain , the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein , which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation , and may be involved in inflammation and immune regulation. [provided by RefSeq , Jul 2013] ,
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Function:
Caution:It is uncertain whether Met-1 or Met-25 is the initiator. ,Function:May activate NF-kappa-B and JNK and promote apoptosis. ,similarity:Contains 1 death domain. ,similarity:Contains 4 TNFR-Cys repeats. ,subunit:Associates with TRADD. ,tissue specificity:Highly expressed in heart , brain , placenta , pancreas , lymph node , thymus and prostate. Detected at lower levels in lung , skeletal muscle , kidney , testis , uterus , small intestine , colon , spleen , bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. ,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
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Research Areas:
>>Cytokine-cytokine receptor interaction
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1317
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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