Synthesized phosho peptide around human CaMKK2 (Ser511)

This antibody detects endogenous levels of Human Mouse Rat CaMKK2 (phospho-Ser511)

CAMKK2 CAMKKB KIAA0787

Calcium/calmodulin-dependent protein kinase kinase 2

CAMKK2 ;
CAMKKB ;
KIAA0787 ;
Calcium/calmodulin-dependent protein kinase kinase 2 ;
CaM-KK 2 ;
CaM-kinase kinase 2 ;
CaMKK 2 ;
Calcium/calmodulin-dependent protein kinase kinase beta ;
CaM-KK beta ;
CaM-kinase kinase beta ;
CaMKK beta

The product of this gene belongs to the Serine/Threonine protein kinase family , and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK) . This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory , neuronal differentiation and migration , neurite outgrowth , and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq , Jul 2012] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Domain:The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. ,Domain:The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates. ,enzyme regulation:Activated by Ca (2+) /calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca (2+) /calmodulin. In part , activity is independent on Ca (2+) /calmodulin. ,Function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1 , isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4 , isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1. ,PTM:Autophosphorylated. ,sequence Caution:Intron retention. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with calmodulin. ,tissue specificity:Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen , prostate , thyroid and leukocytes. The lowest level is in lung. ,

Nucleus . Cytoplasm . Cell projection , neuron projection . Predominantly nuclear in unstimulated cells , relocalizes into cytoplasm and neurites after forskolin induction. .

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>>AMPK signaling pathway ;
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>>Alcoholism