Synthesized phosho peptide around human BMAL1 (Ser42)

This antibody detects endogenous levels of Human Mouse Rat BMAL1 (phospho-Ser42)

ARNTL BHLHE5 BMAL1 MOP3 PASD3

BMAL1 (Ser42)

Aryl hydrocarbon receptor nuclear translocator-like protein 1 ;
Basic-helix-loop-helix-PAS protein MOP3 ;
Brain and muscle ARNT-like 1 ;
Class E basic helix-loop-helix protein 5 ;
bHLHe5 ;
Member of PAS protein 3 ;
PAS domain-containing protein 3 ;
bHLH-PAS protein JAP3 ;

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1 , PER2 , PER3) and Cryptochrome (CRY1 , CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility , problems with gluconeogenesis and lipogenesis , and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2014] ,

Alternative products:Additional isoforms seem to exist ,Function:ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER , and also by CRY proteins. ,miscellaneous:CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and , disrupt circadian rhythmicity. ,PTM:Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression. ,PTM:Phosphorylated upon dimerization with CLOCK. ,PTM:Sumoylated on Lys-259 upon dimerization with CLOCK. ,similarity:Contains 1 basic helix-loop-helix (bHLH) domain. ,similarity:Contains 1 PAC (PAS-associated C-terminal) domain. ,similarity:Contains 2 PAS (PER-ARNT-SIM) domains. ,subunit:Component of the circadian clock oscillator which includes the CRY proteins , CLOCK or NPAS2 , ARNTL or ARNTL2 , CSNK1D and/or CSNK1E , TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation , for CLOCK nuclear translocation and degradation , and , for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro , but not in vivo. ,tissue specificity:Highly expressed in the adult brain , skeletal muscle and heart. ,

Nucleus . Cytoplasm . Nucleus , PML body . Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK , target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. .

>>Circadian rhythm ;
>>Dopaminergic synapse