Catalog: YP1272
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
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Collected
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Main Information
Target
BAP1 Phospho Ser592
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
80kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human BAP1 (phospho-Ser592)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
80kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human BAP1 (Ser592)
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Specificity:
This antibody detects endogenous levels of Human BAP1 (phospho-Ser592)
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Gene Name:
BAP1 KIAA0272 hucep-6
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Protein Name:
BAP1 (Ser592)
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Other Name:
Ubiquitin carboxyl-terminal hydrolase BAP1 ;
BRCA1-associated protein 1 ;
Cerebral protein 6 ;
BRCA1-associated protein 1 ;
Cerebral protein 6 ;
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Database Link:
Background:
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition , the enzyme may be involved in regulation of transcription , regulation of cell cycle and growth , response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS) , which involves increased risk of cancers including malignant mesothelioma , uveal melanoma and cutaneous melanoma. [provided by RefSeq , May 2013] ,
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Function:
Catalytic activity:Thiol-dependent hydrolysis of ester , thioester , amide , peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) . ,Disease:Defects in BAP1 are found in non-small cell lung cancer (NSCLC) cell lines. ,Disease:Tumor-associated antigen found in several childhood medulloblastoma. ,Function:Deubiquitinating enzyme which may be involved in BRCA1 signal transduction pathway. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the peptidase C12 family. ,subunit:Interacts with the RING finger domain of BRCA1. ,tissue specificity:Highly expressed in testis , placenta and ovary. Expressed in breast. ,
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Cellular Localization:
Cytoplasm . Nucleus . Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950) . .
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YP1272
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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