Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL6R

Interleukin-6 receptor subunit alpha

IL6R ;
Interleukin-6 receptor subunit alpha ;
IL-6 receptor subunit alpha ;
IL-6R subunit alpha ;
IL-6R-alpha ;
IL-6RA ;
IL-6R 1 ;
Membrane glycoprotein 80 ;
gp80 ;
CD antigen CD126

domain:The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.,function:Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.,PTM:A short soluble form may also be released from the membrane by proteolysis.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:Hexamer of two molecules each of IL6, IL6R and IL6ST.,tissue specificity:Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.,

regulation of cytokine production, negative regulation of cytokine production, positive regulation of cytokine production, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, response to molecule of bacterial origin, organ or tissue specific immune response, immune effector process, hepatic immune response, leukocyte mediated immunity, myeloid leukocyte mediated immunity, neutrophil mediated immunity, acute inflammatory response, monocyte chemotaxis, positive regulation of immune system process, regulation of leukocyte migration, positive regulation of leukocyte migration, regulation of leukocyte chemotaxis, positive regulation of leukocyte chemotaxis, cell motion, chemotaxis, defense response, acute-phase response, inflammatory response, immune response, behavior, locomotory behavior, positive regulation of cell proliferation, response to radiation, response to wounding, response to bacterium, response to abiotic stimulus,response to endogenous stimulus, response to hormone stimulus, negative regulation of biosynthetic process,positive regulation of signal transduction, response to organic substance, response to ionizing radiation, response to gamma radiation, regulation of activation of Janus kinase activity, positive regulation of activation of Janus kinase activity, negative regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of cell communication, regulation of collagen metabolic process, negative regulation of collagen metabolic process, positive regulation of protein kinase cascade,regulation of cell death, cell migration, regulation of phosphate metabolic process, cytokine-mediated signaling pathway, regulation of ossification, regulation of cell migration, positive regulation of cell migration, leukocyte chemotaxis, pancreas development, endocrine pancreas development, regulation of protein modification process,positive regulation of protein modification process, response to corticosteroid stimulus, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of cellular protein metabolic process,positive regulation of cellular protein metabolic process, response to lipopolysaccharide, regulation of chemokine production, regulation of interleukin-6 production, regulation of interleukin-8 production, negative regulation of interleukin-8 production, positive regulation of chemokine production, positive regulation of interleukin-6 production,regulation of collagen biosynthetic process, negative regulation of collagen biosynthetic process, response to cytokine stimulus, endocrine system development, regulation of locomotion, positive regulation of locomotion, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, taxis, regulation of tyrosine phosphorylation of STAT protein, regulation of tyrosine phosphorylation of Stat3 protein, positive regulation of tyrosine phosphorylation of Stat3 protein, positive regulation of tyrosine phosphorylation of STAT protein, defense response to bacterium, regulation of apoptosis, regulation of programmed cell death, regulation of MAPKKK cascade,positive regulation of MAPKKK cascade, response to peptide hormone stimulus, regulation of multicellular organismal metabolic process, negative regulation of multicellular organismal metabolic process, response to ethanol, positive regulation of cell differentiation, regulation of osteoblast differentiation, positive regulation of osteoblast differentiation, regulation of anti-apoptosis, positive regulation of anti-apoptosis, positive regulation of phosphate metabolic process, regulation of JAK-STAT cascade, positive regulation of JAK-STAT cascade, positive regulation of behavior, response to steroid hormone stimulus, positive regulation of response to stimulus, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, cell motility, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of behavior, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, leukocyte migration, regulation of chemotaxis, positive regulation of chemotaxis, positive regulation of developmental process, regulation of phosphorus metabolic process, positive regulation of multicellular organismal process, negative regulation of multicellular organismal process, positive regulation of protein metabolic process, regulation of cell motion, positive regulation of cell motion, response to glucocorticoid stimulus, response to cAMP, localization of cell, cell chemotaxis,interleukin-6-mediated signaling pathway, ciliary neurotrophic factor-mediated signaling pathway,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .; [Soluble interleukin-6 receptor subunit alpha]: Secreted .

[Isoform 2]: Expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 1%-20% of the total sIL6R in plasma is generated by alternative splicing (PubMed:28060820).