Synthesized phosho peptide around human AS160 (Ser318)

This antibody detects endogenous levels of Human AS160 (phospho-Ser318)

TBC1D4 AS160 KIAA0603

AS160 (Ser318)

TBC1D4 ;
AS160 ;
KIAA0603 ;
TBC1 domain family member 4 ;
Akt substrate of 160 kDa ;
AS160

This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein , and contains two phopshotyrosine-binding domains (PTB1 and PTB2) , a calmodulin-binding domain (CBD) , a Rab-GTPase domain , and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4) , important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane , suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin , this protein is phosphorylated , dissociates from GLUT4 vesicles , resulting in increased GLUT4 at the cell surface , and enhanced glucose transport. Ph

Disease:May be involved in atopic dermatitis (AD) . ,Function:May act as a GTPase-activating protein for RAB2A , RAB8A , RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane , thus increasing glucose uptake. ,PTM:Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. ,PTM:Phosphorylated by AKT1; insulin-induced. ,PTM:Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients. ,similarity:Contains 1 Rab-GAP TBC domain. ,similarity:Contains 2 PID domains. ,subcellular location:Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells. ,tissue specificity:Widely expressed , but differential expression for isoforms 1 and 2 , with highest overall expression of isoform 2 in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart , but was not detectable in the liver nor in adipose tissue. Isoform 2 strongly expressed in adrenal and thyroid gland , and also in lung , kidney , colon , brain and adipose tissue. Moderate isoform 2 expression in skeletal muscle. Expressed in pancreatic Langerhans islets , including beta cells (at protein level) . Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. ,

Cytoplasm . Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.

>>Thyroid hormone signaling pathway ;
>>Insulin resistance ;
>>Diabetic cardiomyopathy