function:Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.,similarity:Belongs to the IL-34 family.,subunit:Homodimer.,tissue specificity:Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.,
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Function:
regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, regulation of phosphate metabolic process, regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, positive regulation of phosphate metabolic process, regulation of phosphorus metabolic process, positive regulation of protein metabolic process,
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Cellular Localization:
Secreted .
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Tissue Expression:
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.