Catalog: YK0001
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
Histone H1 Acetyl Lys25
Host Species
Rabbit
Reactivity
Human, Monkey
Applications
WB, IHC, IF, ELISA
MW
20kD (Observed)
Conjugate/Modification
Acetyl
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Acetyl-Histone H1 (K25) Polyclonal Antibody detects endogenous levels of Histone H1 protein only when acetylated at K25.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EAkED
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
20kD
Modification
Acetyl
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Histone H1 around the acetylated site of Lys25. AA range:131-180
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Specificity:
Acetyl-Histone H1 (K25) Polyclonal Antibody detects endogenous levels of Histone H1 protein only when acetylated at K25.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EAkED
show all
Gene Name:
H1FOO
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Protein Name:
Histone H1oo
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Other Name:
H1FOO ;
H1OO ;
OSH1 ;
Histone H1oo ;
Oocyte-specific histone H1 ;
Oocyte-specific linker histone H1 ;
osH1 ;
H1K25AC
H1OO ;
OSH1 ;
Histone H1oo ;
Oocyte-specific histone H1 ;
Oocyte-specific linker histone H1 ;
osH1 ;
H1K25AC
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Background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015],
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Function:
Function:May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.,similarity:Belongs to the histone H1/H5 family.,tissue specificity:Oocyte-specific.,
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Cellular Localization:
Cytoplasm . Nucleus . Chromosome .
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Tissue Expression:
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Reference Citation({{totalcount}})
Catalog: YK0001
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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