Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TIMP1

Metalloproteinase inhibitor 1

TIMP1 ;
CLGI ;
TIMP ;
Metalloproteinase inhibitor 1 ;
Erythroid-potentiating activity ;
EPA ;
Fibroblast collagenase inhibitor ;
Collagenase inhibitor ;
Tissue inhibitor of metalloproteinases 1 ;
TIMP-1

function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.,PTM:The activity of TIMP1 is dependent on the presence of disulfide bonds.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,

immune system development, positive regulation of cell proliferation, regulation of catabolic process, negative regulation of catabolic process, negative regulation of macromolecule metabolic process, developmental maturation,hemopoiesis, myeloid cell differentiation, regulation of proteolysis, erythrocyte differentiation, regulation of cellular catabolic process, negative regulation of cellular catabolic process, regulation of cellular protein metabolic process,negative regulation of cellular protein metabolic process, erythrocyte homeostasis, regulation of cell proliferation,regulation of protein catabolic process, negative regulation of protein catabolic process, homeostatic process,erythrocyte maturation, negative regulation of proteolysis, cell maturation, hemopoietic or lymphoid organ development, erythrocyte development, homeostasis of number of cells, regulation of membrane protein ectodomain proteolysis, negative regulation of membrane protein ectodomain proteolysis, negative regulation of protein metabolic process,

Secreted .

Detected in rheumatoid synovial fluid (at protein level).