Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

KITLG

Kit ligand

KITLG ;
MGF ;
SCF ;
Kit ligand ;
Mast cell growth factor ;
MGF ;
Stem cell factor ;
SCF ;
c-Kit ligand

developmental stage:Acts in the early stages of hematopoiesis.,function:Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins.,polymorphism:Genetic variations in KITLG are associated with variation in skin/hair/eye pigmentation type 7 (SHEP7) [MIM:611664]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.,PTM:A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.,PTM:Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.,similarity:Belongs to the SCF family.,subcellular location:Also exists as a secreted soluble form (isoform 1 only).,subunit:Homodimer, non-covalently linked.,

ameboidal cell migration, neural crest cell migration, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, immune system development, regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, regulation of DNA replication, cell motion, cell adhesion, cell proliferation, positive regulation of cell proliferation, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, mesenchymal cell development, neural crest cell development, neural crest cell differentiation, cell migration, regulation of phosphate metabolic process, biological adhesion, hemopoiesis,positive regulation of cellular biosynthetic process, regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, positive regulation of kinase activity, regulation of cell proliferation, regulation of phosphorylation,positive regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity,positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function,positive regulation of cell differentiation, regulation of melanocyte differentiation, positive regulation of melanocyte differentiation, regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation, positive regulation of DNA replication, regulation of protein kinase activity, positive regulation of protein kinase activity,positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of phosphate metabolic process, regulation of pigmentation during development, positive regulation of pigmentation during development, hemopoietic or lymphoid organ development, mesenchymal cell differentiation, cell motility,regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of pigment cell differentiation, positive regulation of pigment cell differentiation, regulation of DNA metabolic process,positive regulation of DNA metabolic process, positive regulation of developmental process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of protein metabolic process, regulation of transferase activity, positive regulation of transferase activity, localization of cell,mesenchyme development,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium . Cell projection, filopodium .; [Soluble KIT ligand]: Secreted.