Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

PGF

Placenta growth factor

PGF ;
PGFL ;
PLGF ;
Placenta growth factor ;
PlGF

domain:PLGF-2 contains a basic insert which acts as a cell retention signal.,function:Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner.,PTM:N-glycosylated.,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:The three forms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.,subunit:Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGF/VEGF-A. PlGF-3 is found both as homodimer and as monomer.,tissue specificity:While the three forms are present in most placental tissues, the PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.,

angiogenesis, blood vessel development, urogenital system development, metanephros development, ureteric bud development, branching involved in ureteric bud morphogenesis, response to hypoxia, morphogenesis of a branching structure, kidney development, regulation of endothelial cell proliferation, positive regulation of endothelial cell proliferation, vasculature development, morphogenesis of an epithelium, cell-cell signaling, female pregnancy, cell proliferation, positive regulation of cell proliferation, response to endogenous stimulus, response to hormone stimulus,response to organic substance, cellular response to hormone stimulus, tube morphogenesis, tube development,regulation of cell proliferation, response to drug, blood vessel morphogenesis, tissue morphogenesis, branching morphogenesis of a tube, regulation of cell division, positive regulation of cell division, epithelium development,epithelial tube morphogenesis, ureteric bud morphogenesis, response to oxygen levels,

Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.