Catalog: YP1862
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
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Main Information
Target
MKP-1 Phospho Ser323
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, WB
MW
39kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of MKP-1 (Phospho Ser323) Rabbit pAb at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AGsPA
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
39kD
Modification
Phospho
Clonality
Polyclonal
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human MKP-1 (Phospho Ser323)
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Specificity:
This antibody detects endogenous levels of MKP-1 (Phospho Ser323) Rabbit pAb at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AGsPA
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Gene Name:
DUSP1 CL100 MKP1 PTPN10 VH1
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Protein Name:
Dual specificity protein phosphatase 1 (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
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Other Name:
Dual specificity protein phosphatase 1 ;
EC 3.1.3.48 ;
Dual specificity protein phosphatase hVH1 ;
Mitogen-activated protein kinase phosphatase 1 ;
MAP kinase phosphatase 1 ;
MKP-1 ;
Protein-tyrosine phosphatase CL100 ;
EC 3.1.3.48 ;
Dual specificity protein phosphatase hVH1 ;
Mitogen-activated protein kinase phosphatase 1 ;
MAP kinase phosphatase 1 ;
MKP-1 ;
Protein-tyrosine phosphatase CL100 ;
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Database Link:
Background:
dual specificity phosphatase 1(DUSP1) Homo sapiens The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferati
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Function:
Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'.,induction:By oxidative stress and heat shock.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Research Areas:
>>MAPK signaling pathway ;
>>Serotonergic synapse ;
>>Parkinson disease ;
>>Fluid shear stress and atherosclerosis
>>Serotonergic synapse ;
>>Parkinson disease ;
>>Fluid shear stress and atherosclerosis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1862
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
Add to cart
Collected
Collect
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