Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL1A

Interleukin-1 alpha

IL1A ;
IL1F1 ;
Interleukin-1 alpha ;
IL-1 alpha ;
Hematopoietin-1

domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Monomer.,

temperature homeostasis, fever, regulation of cytokine production, positive regulation of cytokine production, acute inflammatory response, apoptosis, anti-apoptosis, defense response, acute-phase response, inflammatory response,immune response, regulation of mitosis, regulation of mitotic cell cycle, cell death, cell proliferation, negative regulation of cell proliferation, response to wounding, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, regulation of cell cycle process, regulation of vascular endothelial growth factor production, positive regulation vascular endothelial growth factor production, positive regulation of macromolecule metabolic process, positive regulation of organelle organization, regulation of cell death, programmed cell death,death, cytokine-mediated signaling pathway, positive regulation of cellular biosynthetic process, heat generation,regulation of interleukin-2 production, regulation of protein localization, regulation of organelle organization,regulation of cytokine biosynthetic process, positive regulation of cytokine biosynthetic process, regulation of cell proliferation, homeostatic process, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, regulation of interleukin-2 biosynthetic process, positive regulation of interleukin-2 biosynthetic process, regulation of angiogenesis, positive regulation of angiogenesis, positive regulation of cell cycle, positive regulation of mitosis, multicellular organismal homeostasis,regulation of cytokine secretion, regulation of protein secretion, positive regulation of protein secretion, positive regulation of cytokine secretion, regulation of secretion, positive regulation of secretion, positive regulation of transport, positive regulation of developmental process, positive regulation of cellular component organization,positive regulation of protein transport, regulation of protein transport, positive regulation of multicellular organismal process, regulation of cell division, regulation of cell cycle, positive regulation of cell division, regulation of nuclear division, positive regulation of nuclear division, regulation of cellular localization, negative regulation of cell death,regulation of establishment of protein localization,

Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .