function:Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.,online information:CXCL1 entry,PTM:N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,
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Function:
chemotaxis, defense response, inflammatory response, immune response, cytoskeleton organization, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, intracellular signaling cascade, behavior, locomotory behavior, cell proliferation, negative regulation of cell proliferation, response to wounding, actin filament-based process, actin cytoskeleton organization, regulation of cell proliferation, taxis,