Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

PROK1

Prokineticin-1

PROK1 ;
Prokineticin-1 ;
Endocrine-gland-derived vascular endothelial growth factor ;
EG-VEGF ;
Mambakine

developmental stage:In adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis.,function:Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.,similarity:Belongs to the AVIT (prokineticin) family.,tissue specificity:Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.,

MAPKKK cascade, activation of MAPK activity, angiogenesis, blood vessel development, vasculature development,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, positive regulation of cell proliferation, phosphorylation, regulation of phosphate metabolic process, positive regulation of kinase activity, regulation of cell proliferation, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of angiogenesis,regulation of protein kinase activity, positive regulation of protein kinase activity, blood vessel morphogenesis,regulation of phosphorus metabolic process, regulation of cell division, regulation of transferase activity, positive regulation of transferase activity, positive regulation of cell division,

Secreted.

Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.