Catalog: YP1822
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
Add to cart
Collected
Collect
Main Information
Target
CTIP Phospho Ser664
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, WB
MW
100kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of RBBP8 (Phospho Ser664) Rabbit pAb at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DLsQY
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
100kD
Modification
Phospho
Clonality
Polyclonal
Related Products
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
More→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
More→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
More→
Antigen&Target Information
Immunogen:
Synthesized peptide derived from human RBBP8 (Phospho Ser664)
show all
Specificity:
This antibody detects endogenous levels of RBBP8 (Phospho Ser664) Rabbit pAb at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DLsQY
show all
Gene Name:
RBBP8 CTIP
show all
Protein Name:
DNA endonuclease RBBP8 (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)
show all
Other Name:
DNA endonuclease RBBP8 ;
CtBP-interacting protein ;
CtIP ;
Retinoblastoma-binding protein 8 ;
RBBP-8 ;
Retinoblastoma-interacting protein and myosin-like ;
RIM ;
Sporulation in the absence of SPO11 protein 2 homolog ;
SAE2 ;
CtBP-interacting protein ;
CtIP ;
Retinoblastoma-binding protein 8 ;
RBBP-8 ;
Retinoblastoma-interacting protein and myosin-like ;
RIM ;
Sporulation in the absence of SPO11 protein 2 homolog ;
SAE2 ;
show all
Database Link:
Background:
RB binding protein 8, endonuclease(RBBP8) Homo sapiens The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008],
show all
Function:
Function:May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,subcellular location:Predominantly nuclear.,subunit:Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein.,
show all
Cellular Localization:
Nucleus . Chromosome . Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). .
show all
Tissue Expression:
Research Areas:
>>Homologous recombination
show all
Reference Citation({{totalcount}})
Catalog: YP1822
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}