Catalog: YP1813
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
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Collected
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Main Information
Target
DAPK1 Phospho Ser289
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, WB
MW
157kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of DAPK1 (Phospho Ser289) Rabbit pAb at Human, Mouse
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
157kD
Modification
Phospho
Clonality
Polyclonal
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human DAPK1 (Phospho Ser289)
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Specificity:
This antibody detects endogenous levels of DAPK1 (Phospho Ser289) Rabbit pAb at Human, Mouse
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Gene Name:
DAPK1 DAPK
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Protein Name:
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
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Other Name:
Death-associated protein kinase 1 ;
DAP kinase 1 ;
DAP kinase 1 ;
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Background:
death associated protein kinase 1(DAPK1) Homo sapiens Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Negatively regulated by autophosphorylation on Ser-308.,Function:Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.,induction:Up-regulated following treatment with interferon-gamma.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 10 ANK repeats.,subcellular location:Colocalizes with the actin filament system.,
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Cellular Localization:
[Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Colocalizes with MAP1B in the microtubules and cortical actin fibers.; [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton.
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Tissue Expression:
Research Areas:
>>Autophagy - animal ;
>>Pathways in cancer ;
>>Bladder cancer
>>Pathways in cancer ;
>>Bladder cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1813
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
Add to cart
Collected
Collect
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