Catalog: YP1743
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
Bag-3 Phospho Tyr457
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
63kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of BAG3 (Phospho-Tyr457) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EEyLT
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
63kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
Antigen&Target Information
Immunogen:
Synthesized peptide derived from human BAG3 (Phospho-Tyr457)
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Specificity:
This antibody detects endogenous levels of BAG3 (Phospho-Tyr457) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EEyLT
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Gene Name:
BAG3 BIS
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Protein Name:
BAG3 (Phospho-Tyr457)
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Other Name:
BAG3 ;
BIS ;
BAG family molecular chaperone regulator 3 ;
BAG-3 ;
Bcl-2-associated athanogene 3 ;
Bcl-2-binding protein Bis ;
Docking protein CAIR-1
BIS ;
BAG family molecular chaperone regulator 3 ;
BAG-3 ;
Bcl-2-associated athanogene 3 ;
Bcl-2-binding protein Bis ;
Docking protein CAIR-1
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Background:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
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Function:
Function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.,similarity:Contains 1 BAG domain.,similarity:Contains 2 WW domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds to Bcl-2 and PLC-gamma.,
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Cellular Localization:
Nucleus . Cytoplasm . Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). .
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YP1743
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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