Catalog: YP1737
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
PDE3A Phospho Ser312
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
126kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of PDE3A (Phospho-Ser312) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RTsLP
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
126kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
Antigen&Target Information
Immunogen:
Synthesized peptide derived from human PDE3A (Phospho-Ser312)
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Specificity:
This antibody detects endogenous levels of PDE3A (Phospho-Ser312) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RTsLP
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Gene Name:
PDE3A
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Protein Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
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Other Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A ;
Cyclic GMP-inhibited phosphodiesterase A ;
CGI-PDE A ;
cGI-PDE ;
cGMP-inhibited cAMP phosphodiesterase ;
Cyclic GMP-inhibited phosphodiesterase A ;
CGI-PDE A ;
cGI-PDE ;
cGMP-inhibited cAMP phosphodiesterase ;
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Database Link:
Background:
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
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Function:
Catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Inhibited by cGMP.,Function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,online information:PDE3 entry,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,
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Cellular Localization:
Membrane ; Multi-pass membrane protein . Cytoplasm, cytosol .
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Tissue Expression:
Research Areas:
>>Purine metabolism ;
>>Metabolic pathways ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Renin secretion ;
>>Morphine addiction
>>Metabolic pathways ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Renin secretion ;
>>Morphine addiction
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1737
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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