DYRK2/4 (Phospho Tyr382/264) Rabbit pAb

-YP1736

Catalog: YP1736
Size
Price
Status
Qty.
200μL
$600.00
In stock

0

100μL
$340.00
In stock

0

50μL
$190.00
In stock

0

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Main Information
Target

DYRK2/4 Phospho Tyr382/264

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB

MW

66kD (Calculated)

Conjugate/Modification


Phospho

Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of DYRK2/4 only when phosphorylated at Tyr382/264..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YTyQS
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
66kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
Antigen&Target Information
Immunogen:
Synthesized peptide derived from human DYRK2/4 (Phospho-Tyr382/264)
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Specificity:
This antibody detects endogenous levels of DYRK2/4 only when phosphorylated at Tyr382/264..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YTyQS
show all
Gene Name:
DYRK2
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Protein Name:
DYRK2/4 (Phospho-Tyr382/264)
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Other Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2 ;
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Database Link:
Organism Gene ID SwissProt
Human 8445; Q92630;
Mouse 69181; Q5U4C9;
Background:
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,cofactor:Manganese.,enzyme regulation:Autophosphorylates on tyrosine residues.,Function:Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.,PTM:Phosphorylated on serine/threonine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Translocates into the nucleus following DNA damage.,tissue specificity:Testis, after the onset of spermatogenesis.,
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Cellular Localization:
Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
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Tissue Expression:
Catalog: YP1736
Size
Price
Status
Qty.
200μL
$600.00
In stock

0

100μL
$340.00
In stock

0

50μL
$190.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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