Catalog: YP1726
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
EphB1/3/4 Phospho Tyr778/792/774
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
108kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of EPHB1 only when phosphorylated at thr778 and EPHB3 only when phosphorylated at thr792 and EPHB4 only when phosphorylated at thr794, .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PTyTS
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
108kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human EPH B1/3/4 (Phospho-Tyr778/792/774)
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Specificity:
This antibody detects endogenous levels of EPHB1 only when phosphorylated at thr778 and EPHB3 only when phosphorylated at thr792 and EPHB4 only when phosphorylated at thr794, .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PTyTS
show all
Gene Name:
EPHB1 ELK EPHT2 HEK6 NET
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Protein Name:
EPH B1/3/4 (Phospho-Tyr778/792/774)
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Other Name:
Ephrin type-B receptor 1 ;
ELK ;
EPH tyrosine kinase 2 ;
EPH-like kinase 6 ;
EK6 ;
hEK6 ;
Neuronally-expressed EPH-related tyrosine kinase ;
NET ;
Tyrosine-protein kinase receptor EPH-2 ;
ELK ;
EPH tyrosine kinase 2 ;
EPH-like kinase 6 ;
EK6 ;
hEK6 ;
Neuronally-expressed EPH-related tyrosine kinase ;
NET ;
Tyrosine-protein kinase receptor EPH-2 ;
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Database Link:
Background:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. Interacts with EPHB6. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP.,tissue specificity:Preferentially expressed in brain.,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, dendrite .
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Tissue Expression:
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Research Areas:
>>Axon guidance
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Reference Citation({{totalcount}})
Catalog: YP1726
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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