Catalog: YP1593
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
Calpain 2 Phospho Ser50
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
69kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat Calpain 2 (Phospho Ser50).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DPsFP
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
69kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Calpain 2 (Phospho Ser50)
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Specificity:
This antibody detects endogenous levels of Human,Mouse,Rat Calpain 2 (Phospho Ser50).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DPsFP
show all
Gene Name:
CAPN2 CANPL2
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Protein Name:
Calpain-2 catalytic subunit (Phospho Ser50)
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Other Name:
CAPN2 ;
CANPL2 ;
Calpain-2 catalytic subunit ;
Calcium-activated neutral proteinase 2 ;
CANP 2 ;
Calpain M-type ;
Calpain large polypeptide L2 ;
Calpain-2 large subunit ;
Millimolar-calpain ;
M-calpain
CANPL2 ;
Calpain-2 catalytic subunit ;
Calcium-activated neutral proteinase 2 ;
CANP 2 ;
Calpain M-type ;
Calpain large polypeptide L2 ;
Calpain-2 large subunit ;
Millimolar-calpain ;
M-calpain
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Database Link:
Background:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
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Function:
Catalytic activity:Broad endopeptidase specificity.,cofactor:Binds 3 calcium ions.,enzyme regulation:Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.,Function:Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 3 EF-hand domains.,subcellular location:Translocates to the plasma membrane upon Ca(2+) binding.,subunit:Forms a heterodimer with a small (regulatory) subunit (CAPNS1).,tissue specificity:Ubiquitous.,
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Cellular Localization:
Cytoplasm. Cell membrane. Translocates to the plasma membrane upon Ca(2+) binding.
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Tissue Expression:
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Research Areas:
>>Protein processing in endoplasmic reticulum ;
>>Apoptosis ;
>>Necroptosis ;
>>Cellular senescence ;
>>Focal adhesion ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis
>>Apoptosis ;
>>Necroptosis ;
>>Cellular senescence ;
>>Focal adhesion ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Necroptosis
Cellular Processes >> Cell growth and death >> Cellular senescence
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
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Catalog: YP1593
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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