Catalog: YP1497
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
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Main Information
Target
SLP-76 Phospho Ser376
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA, IHC
MW
75kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse SLP-76 (phospho-Ser376)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
75kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human SLP-76 (Ser376)
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Specificity:
This antibody detects endogenous levels of Human Mouse SLP-76 (phospho-Ser376)
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Gene Name:
LCP2
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Protein Name:
SLP-76 (Ser376)
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Other Name:
Lymphocyte cytosolic protein 2 ;
SH2 domain-containing leukocyte protein of 76 kDa ;
SLP-76 tyrosine phosphoprotein ;
SLP76 ;
SH2 domain-containing leukocyte protein of 76 kDa ;
SLP-76 tyrosine phosphoprotein ;
SLP76 ;
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Background:
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T c
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Function:
Domain:The SH2 domain mediates interaction with SHB.,Function:Involved in T-cell antigen receptor mediated signaling.,PTM:Phosphorylated after T-cell receptor activation by ZAP-70.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1.,tissue specificity:Highly expressed in spleen, thymus, and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblasatoma cell lines.,
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Cellular Localization:
Cytoplasm .
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Tissue Expression:
Research Areas:
>>Rap1 signaling pathway ;
>>Osteoclast differentiation ;
>>Platelet activation ;
>>Natural killer cell mediated cytotoxicity ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>Yersinia infection
>>Osteoclast differentiation ;
>>Platelet activation ;
>>Natural killer cell mediated cytotoxicity ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>Yersinia infection
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Signaling Pathway
Organismal Systems >> Immune system >> Platelet activation
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway
Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Reference Citation({{totalcount}})
Catalog: YP1497
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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