Catalog: YP1494
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
SIN1 Phospho Thr86
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA, IHC
MW
58kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Sin1 (phospho-Thr86)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
58kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human Sin1 (Thr86)
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Specificity:
This antibody detects endogenous levels of Human Mouse Sin1 (phospho-Thr86)
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Gene Name:
MAPKAP1 MIP1 SIN1
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Protein Name:
Target of rapamycin complex 2 subunit MAPKAP1
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Other Name:
Target of rapamycin complex 2 subunit MAPKAP1 ;
TORC2 subunit MAPKAP1 ;
Mitogen-activated protein kinase 2-associated protein 1 ;
Stress-activated map kinase-interacting protein 1 ;
SAPK-interacting protein 1 ;
mSIN1 ;
TORC2 subunit MAPKAP1 ;
Mitogen-activated protein kinase 2-associated protein 1 ;
Stress-activated map kinase-interacting protein 1 ;
SAPK-interacting protein 1 ;
mSIN1 ;
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Database Link:
Background:
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008],
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Function:
Function:Essential component of the TORC2 complex, which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. Inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAs signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.,similarity:Belongs to the SIN1 family.,subunit:All isoforms except isoform 4 are able to be part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2.,tissue specificity:Ubiquitously expressed, with highest levels in heart and skeletal muscle.,
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Cellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
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Tissue Expression:
Research Areas:
>>mTOR signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1494
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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