Catalog: YP1486
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
SGK3 Phospho Thr320
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
54kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human SGK3 (phospho-Thr320)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
54kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human SGK3 (Thr320)
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Specificity:
This antibody detects endogenous levels of Human SGK3 (phospho-Thr320)
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Gene Name:
SGK3 CISK SGKL
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Protein Name:
Serine/threonine-protein kinase Sgk3
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Other Name:
Serine/threonine-protein kinase Sgk3 ;
Cytokine-independent survival kinase ;
Serum/glucocorticoid-regulated kinase 3 ;
Serum/glucocorticoid-regulated kinase-like ;
Cytokine-independent survival kinase ;
Serum/glucocorticoid-regulated kinase 3 ;
Serum/glucocorticoid-regulated kinase-like ;
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Database Link:
Background:
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation.,Function:Involved in the activation of potassium channels. Mediates cell IL-3-dependent survival signals.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 PX (phox homology) domain.,subcellular location:Localized in vesicle-like structures and in the early endosome.,tissue specificity:Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle.,
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Cellular Localization:
Cytoplasmic vesicle . Early endosome. Recycling endosome. Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
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Tissue Expression:
Research Areas:
>>FoxO signaling pathway ;
>>PI3K-Akt signaling pathway
>>PI3K-Akt signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1486
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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