Synthesized phosho peptide around human MKK7 (Ser271 and Thr275)

This antibody detects endogenous levels of MKK7 only when phosphorylated at Ser271 or Thr275,and dually phosphorylated at two sites.

MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4

MKK7 (Ser271/Thr275)

Dual specificity mitogen-activated protein kinase kinase 7 ;
MAP kinase kinase 7 ;
MAPKK 7 ;
JNK-activating kinase 2 ;
MAPK/ERK kinase 7 ;
MEK 7 ;
Stress-activated protein kinase kinase 4 ;
SAPK kinase 4 ;
SAPKK-4 ;
SAPKK4 ;
c-Jun N-terminal kinase kinase 2 ;
JNK kinase 2 ;
JNKK 2 ;

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,Function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.,

Nucleus. Cytoplasm .

>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Protein processing in endoplasmic reticulum ;
>>Osteoclast differentiation ;
>>Tight junction ;
>>Toll-like receptor signaling pathway ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>TNF signaling pathway ;
>>Neurotrophin signaling pathway ;
>>GnRH signaling pathway ;
>>Relaxin signaling pathway ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Salmonella infection ;
>>Yersinia infection ;
>>Hepatitis B ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis