Synthesized phosho peptide around human LRP6 (Ser1490)

This antibody detects endogenous levels of Human LRP6 (phospho-Ser1490).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PPsPA

LRP6

LRP6 (Ser1490)

Low-density lipoprotein receptor-related protein 6 ;
LRP-6 ;

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],

Disease:Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947].,Domain:The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1.,Function:Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.,similarity:Belongs to the LDLR family.,similarity:Contains 20 LDL-receptor class B repeats.,similarity:Contains 3 LDL-receptor class A domains.,similarity:Contains 4 EGF-like domains.,subunit:Interacts with RSPO1 and RSPO3 (By similarity). Interacts with FZD5. Essential component of the Wnt7 receptor complex. Wnt7A interacts with the LRP6/FZD5 complex. This interaction is antagonized by DKK1 and DKK3.,tissue specificity:Widely co-expressed with LRP5 during embryogenesis and in adult tissues.,

Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum . Membrane raft . On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). .

>>mTOR signaling pathway ;
>>Wnt signaling pathway ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathways in cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer