Catalog: YP1385
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
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Main Information
Target
LDHA Phospho Tyr10
Host Species
Rabbit
Reactivity
Human
Applications
WB, ELISA, IHC
MW
36kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
36kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human LDHA (Tyr10)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10)
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Gene Name:
LDHA PIG19
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Protein Name:
LDHA (Tyr10)
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Other Name:
L-lactate dehydrogenase A chain ;
LDH-A ;
Cell proliferation-inducing gene 19 protein ;
LDH muscle subunit ;
LDH-M ;
Renal carcinoma antigen NY-REN-59 ;
LDH-A ;
Cell proliferation-inducing gene 19 protein ;
LDH muscle subunit ;
LDH-M ;
Renal carcinoma antigen NY-REN-59 ;
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Database Link:
Background:
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],
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Function:
Catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer.,
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Cellular Localization:
Cytoplasm.
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Tissue Expression:
Research Areas:
>>Glycolysis / Gluconeogenesis ;
>>Cysteine and methionine metabolism ;
>>Pyruvate metabolism ;
>>Propanoate metabolism ;
>>Metabolic pathways ;
>>HIF-1 signaling pathway ;
>>Glucagon signaling pathway ;
>>Central carbon metabolism in cancer
>>Cysteine and methionine metabolism ;
>>Pyruvate metabolism ;
>>Propanoate metabolism ;
>>Metabolic pathways ;
>>HIF-1 signaling pathway ;
>>Glucagon signaling pathway ;
>>Central carbon metabolism in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1385
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
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